Study shows Prescription Diet® Feline x/d™ reduces risk of
Calcium Oxalate Urolithiasis

A recent study at the Minnesota Urolith Center (MUC) supports the role of Prescription Diet® Feline x/d™ in the nutritional management of calcium oxalate (CaOx) urolithiasis in cats. The study demonstrated that hypercalciuria was associated with CaOx uroliths in cats and that a reduction in urine supersaturation with CaOx occurred when cats were fed Prescription Diet® Feline x/d™. These results suggest that consumption of Prescription Diet® Feline x/d™ will reduce recurrence of CaOx urolithiasis.

The study evaluated the effect of commercial cat foods on urine CaOx saturation in ten client-owned cats with CaOx urolithiasis. Using a crossover design, the effect of nutrition on urine activity product ratios (APR) for CaOx was evaluated. Two groups of diets were evaluated including the food each cat consumed prior to urolith detection and Prescription Diet® Feline x/d™ Cats were fed each food for 8 weeks, and at the end of the feeding period, APR's were evaluated and compared. Mean urine APR's for CaOx were significantly lower and urinary CaOx supersaturation was reduced by 59% when cats were fed Prescription Diet® Feline x/d™. Calcium and oxalate are calculogenic minerals and the presence of these minerals in urine is a risk factor for CaOx urolith formation. Therefore, the results of this study suggest that cats fed Prescription Diet® Feline x/d™ will have a reduction in CaOx urolith recurrence. This study reinforces the value of clinical nutrition in the management of feline urolithiasis. Prescription Diet® Feline x/d™ is formulated for the nutritional management of cats with oxalaterelated feline lower urinary tract disease (FLUTD).

Prescription Diet® Feline x/d™ contains added potassium citrate, which results in a higher alkaline urinary pH, increasing urinary excretion of citrate, an inhibitor of calcium oxalate crystallization. High levels of vitamin B6 may decrease oxalate production and urinary excretion, and reduced sodium content may reduce risk of urolithiasis by limiting excess urine calcium excretion.

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